S.-I. Murtada

Short-Term Disruption of TGFβ Signaling in Adult Mice Renders the Aorta Vulnerable to Hypertension-Induced Dissection

This study shows that disrupting TGFβ signaling in adult mice makes the aorta susceptible to hypertension-induced dissection, even from short-term blood pressure increases.

Smooth Muscle Cell Death Drives an Osteochondrogenic Phenotype and Severe Proximal Vascular Disease in Progeria

This study links smooth muscle cell death to osteochondrogenic changes and vascular disease in progeria, identifying a sequence of pathological events leading to cardiovascular complications.

Ex Vivo Biomechanical Characterization of Umbilical Vessels: Possible Shunts in Congenital Heart Palliation

This study biomechanically compares umbilical veins and arteries with subclavian and pulmonary arteries to evaluate their suitability as shunts for congenital heart palliation.

Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford Progeria Syndrome

Lonafarnib improves cardiovascular function and survival in a progeria mouse model by reducing pulse wave velocity and enhancing left ventricular diastolic function.

Genetic Background Dictates Aortic Fibrosis in Hypertensive Mice

This study shows that genetic background strain influences aortic fibrosis in hypertensive mice, with C57BL/6J mice showing more maladaptive remodeling than 129SvEv mice.

Paradoxical Aortic Stiffening and Subsequent Cardiac Dysfunction in Hutchinson-Gilford Progeria Syndrome

This study shows that aortic stiffening and cardiac dysfunction in HGPS mice occur due to loss of smooth muscle function and proteoglycan accumulation, independent of sex, with potential therapeutic implications.