Y. Kawamura

Artificial Intelligence Enables the Label-Free Identification of Chronic Myeloid Leukemia Cells with Mitochondrial Morphological Alterations

This study uses AI with flow cytometry to identify CML cells with mitochondrial morphological changes, enabling early diagnosis and monitoring of treatment response.

Pooled CRISPR screening of high-content cellular phenotypes by ghost cytometry

The paper introduces a ghost cytometry-based method for fast pooled CRISPR screening of high-content cellular phenotypes, including fluorescence and label-free modes, enabling genome-wide analysis of gene effects on cellular processes.

Smooth Muscle Cell Death Drives an Osteochondrogenic Phenotype and Severe Proximal Vascular Disease in Progeria

This study links smooth muscle cell death to osteochondrogenic changes and vascular disease in progeria, identifying a sequence of pathological events leading to cardiovascular complications.

Compensatory aortic remodeling in Marfan syndrome protects against sexually dimorphic rupture during a BAPN challenge

The paper examines sexual dimorphism in aortic remodeling and rupture resistance in Marfan syndrome mice with and without BAPN exposure, finding compensatory mechanisms in females and males that protect against rupture.

Receptor-like kinases FER and SRK mediate Lotus japonicus freezing tolerance and climate adaptation

The paper identifies FER and SRK as genes involved in freezing tolerance and climate adaptation in Lotus japonicus.

Diversity in DNA sequence, structure, and heterozygosity of nuclear rRNA gene region in Neopyropia yezoensis

The paper analyzes DNA sequence, structure, and heterozygosity of nuclear rRNA genes in Neopyropia yezoensis and its relatives, revealing structural variation and heterozygosity patterns.

Lonafarnib improves cardiovascular function and survival in a mouse model of Hutchinson-Gilford Progeria Syndrome

Lonafarnib improves cardiovascular function and survival in a progeria mouse model by reducing pulse wave velocity and enhancing left ventricular diastolic function.

Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats

This study shows naked mole-rats (NMRs) resist chemical carcinogenesis through reduced inflammatory responses linked to necroptosis deficiency.

The Brachypodium distachyon cold-acclimated plasma membrane proteome is primed for stress resistance

This study identifies cold-acclimated plasma membrane proteins in Brachypodium distachyon, revealing stress response mechanisms and potential for improving frost resistance in monocots.

Genetic diversity and population structure of razor clam Sinonovacula constricta in Ariake Bay, Japan, revealed using RAD-Seq SNP markers.

The paper uses RAD-Seq SNP markers to reveal two genetically distinct populations of razor clam Sinonovacula constricta in Ariake Bay, Japan, with significant genetic differentiation.

Senescent cell death as an aging resistance mechanism in naked mole-rat

This study identifies senescent cell death as a mechanism contributing to the aging resistance in naked mole-rats, linking low antioxidant defense with suppressed senescent cell accumulation.

Characterization of brown adipose tissue thermogenesis in the naked mole-rat (Heterocephalus glaber), a poikilothermic mammal

This study investigates brown adipose tissue thermogenesis in naked mole-rats, showing ADRB3-dependent thermogenic activity and its role in thermoregulation in non-cold environments.

Paradoxical Aortic Stiffening and Subsequent Cardiac Dysfunction in Hutchinson-Gilford Progeria Syndrome

This study shows that aortic stiffening and cardiac dysfunction in HGPS mice occur due to loss of smooth muscle function and proteoglycan accumulation, independent of sex, with potential therapeutic implications.

Extreme genetic signatures of local adaptation during plant colonization

The paper investigates genetic adaptations during the colonization of Japan by Lotus japonicus, identifying genomic regions and candidate genes associated with overwintering and flowering time traits.