Targeting Fatty Acid Desaturase I Inhibits Renal Cancer Growth Via ATF3-mediated ER Stress Response
Gioia Heravi, Zhenjie Liu, Mackenzie K. Herroon, Alexis Wilson, Yang-Yi Fan, Yang Jiang, Nivisa Vakeesan, Tao Li, Zheyun Peng, Kezhong Zhang, Jing Li, Robert S. Chapkin, Izabela Podgorski, Wanqing Liu
This study shows that inhibiting FADS1 reduces renal cancer growth by inducing ER stress and ATF3-mediated responses, highlighting FADS1 as a therapeutic target.
Biomedicine & Pharmacotherapy · Mar 23, 2025Peer-reviewedCancer Biology