Gerrit Hilgen

The paper develops vascular organoids that integrate into retinal organoids, revealing diabetic retinopathy-like gene expression patterns in endothelial-like cells.

This study shows that rhythmic light flicker improves photoreceptor maturation in human retinal organoids by enhancing structural development, transcriptional transition, and functional connectivity.

This study identifies a unified mechanism linking retinal waves, apoptosis, and angiogenesis in postnatal mouse retina through purinergic signaling and microglial interactions.

This study demonstrates that AAV-mediated PRPF31 gene therapy restores splicing homeostasis and rescues RP11 phenotypes in patient-derived RPE and retinal organoids.

This paper introduces a novel approach to classify retinal ganglion cells using pharmacogenetics, immunohistochemistry, and electrophysiology, identifying new cell types and their functional responses.

This study shows that transplanted pluripotent stem cell-derived cone precursors can restore light responses in mice with advanced retinal degeneration, despite low engraftment.

This paper presents a non-parametric method for classifying retinal ganglion cells using spike train distance measures and evaluates it on mouse retinal recordings.

The paper generates patient-specific retinal organoids and RPE from RP type 11 patients to show PRPF31 mutations cause retinal-specific splicing defects and structural/functional impairments, which are corrected by in situ gene editing.

This paper introduces an efficient spike sorting method for high-density multielectrode arrays, enabling fast and reliable clustering of millions of events.

The paper characterizes light responses of retinal ganglion cells in developing mouse retinas, revealing developmental differences between dorsal and ventral regions and changes in response strength and receptive field properties.