Laetitia Besse

This study shows that reduced microtubule polyglutamylation causes neuronal dysfunction and worsens Tau-induced neurodegeneration in mice.

This study shows that translational control of 53BP1 mRNA regulates adaptive mutability in melanoma cells, and targeting eIF4A reduces resistance to BRAF/MEK inhibitors.

This study identifies a non-metabolic role for hexokinase 2 as an RNA-binding protein that regulates SOX10 mRNA translation in melanoma, independent of its glycolytic activity.

This study shows that MAFA phosphorylation affects beta-cell identity and sex-specific pancreatic disease outcomes in mice, linking phosphorylation defects to diabetes and mucinous cystic neoplasms.

The paper investigates how SUMO protease and proteasome recruitment at nuclear pores affects replication dynamics at arrested forks in fission yeast.