Lucilla Fabbri

This study shows RNA directly interacts with BRAF to regulate MAPK signaling by facilitating RAF complex formation and MEK1/2 phosphorylation.

This study shows that translational control of 53BP1 mRNA regulates adaptive mutability in melanoma cells, and targeting eIF4A reduces resistance to BRAF/MEK inhibitors.

This study identifies a non-metabolic role for hexokinase 2 as an RNA-binding protein that regulates SOX10 mRNA translation in melanoma, independent of its glycolytic activity.