Selective mRNA translation determines adaptative mutability of melanoma cells to anti-BRAF/MEK combination therapy
Lucilla Fabbri, Lucie Lagadec, Eva Guérin, Hélène Lecourt, Dorothée Baïlle, Laetitia Besse, Cédric Messaoudi, Laurent Désaubry, Hussein Abou‐Hamdan, Sévérine Roy, Bérangère Lombard, Damarys Loew, Jean‐Yves Scoazec, Caroline Robert, Stéphan Vagner
This study shows that translational control of 53BP1 mRNA regulates adaptive mutability in melanoma cells, and targeting eIF4A reduces resistance to BRAF/MEK inhibitors.
EMBO Molecular Medicine · Jul 20, 2026Peer-reviewedCancer Biology