Author

Joel M. Chick

Harvard University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Cancer Biology· 1 Neuroscience· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 4 Research Focus:differential expression· 3 Organism:mouse· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Gary A. ChurchilliD· 2 shared Isabela Gerdes GyuriczaiD· 2 shared Ron KorstanjeiD· 2 shared Steven P. GygiiD· 2 shared Aaron Nathan SneadiD· 1 shared Alex M. JaegeriD· 1 shared Andrew G. DeighaniD· 1 shared Antonio Esparza-OrosiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersGenomics

Gary A. ChurchillORCID

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Author profile →

5 papers

Recent·Most cited

Discovery and Targeting of a Cryptic Human Proteome

Joel M. Chick, Ashley R. Woodfin, Jessica Weir, Marco Blanchette, Ariel S. Schwartz, Leopold Garnar-Wortzel, Christopher A. Polera, Sebastian C.J. Steiniger, Marcus R. Kelly, Kerry Wilson, Jon A. Bass, Alex M. Jaeger, Imad Ajjawi, Corey M. Dambacher

The paper introduces RyboCypher, a platform that maps the dark transcriptome to unannotated peptides, identifying cryptic proteins in cancer cell lines, tumors, and healthy tissues.

bioRxiv · Aug 11, 2026 · PreprintGenomics

Covalent inhibitors of the RAS binding domain of PI3Ka impair tumor growth driven by RAS and HER2

Joseph E. Klebba, Nilotpal Roy, Steffen M. Bernard, Stephanie Grabow, Melissa A. Hoffman, Hui Miao, Junko Tamiya, Jinwei Wang, Cynthia Berry, Antonio Esparza-Oros, Richard D. Lin, Yongsheng Liu, Marie Pariollaud, Holly Parker, Igor Mochalkin, , Matthew P. Patricelli

The paper develops covalent inhibitors targeting the RAS binding domain of PI3Kα, showing efficacy against RAS and HER2-driven tumors without affecting glucose homeostasis.

Science · Oct 9, 2025Peer-reviewedCancer Biology

Genome-wide transcript and protein analysis reveals distinct features of aging in the mouse heart

Isabela Gerdes Gyuricza, Joel M. Chick, Gregory R. Keele, Andrew G. Deighan, Steven C. Munger, Ron Korstanje, Steven P. Gygi, Gary A. Churchill

The paper analyzes transcriptome and proteome data from aged mouse hearts to identify molecular changes associated with aging, revealing distinct biological processes and genetic loci influencing age-related changes.

Genome Research · Mar 11, 2022Peer-reviewedGenomics

Proteomic and transcriptomic profiling reveal different aspects of aging in the kidney

Yuka Takemon, Joel M. Chick, Isabela Gerdes Gyuricza, Daniel A. Skelly, Olivier Devuyst, Steven P. Gygi, Gary A. Churchill, Ron Korstanje

This study profiles mRNA and protein levels in aging kidneys, finding that protein changes reveal more extensive and functionally significant aging-related alterations than mRNA.

eLife · Mar 9, 2021Peer-reviewedSystems Biology

Experimental glaucoma retinal proteomics identifies mutually exclusive and overlapping molecular characteristics with human glaucoma

Mehdi Mirzaei, Vivek Gupta, Nitin Chitranshi, Liting Deng, Kanishka Pushpitha, Mojdeh Abbasi, Joel M. Chick, Rashi Rajput, Yunqi Wu, Matthew J. McKay, Ghasem Hosseini Salekdeh, Veer Bala Gupta, Paul A. Haynes, Stuart L. Graham

This study compares proteomic changes in a rat glaucoma model with human glaucoma, identifying shared and distinct molecular features related to oxidative stress, mitochondrial dysfunction, and immune pathways.

bioRxiv · May 14, 2020 · PreprintNeuroscience