Fatty acid metabolism controls plasma membrane cholesterol accessibility via ATGL-dependent phospholipid remodeling
Kalani M. Wijesinghe, Chai-Wan Kim, Summer Chen, Emily O Schad, Erin Takeshima, Shuo Li, Chandni B. Patel, Dylan Calhoon, Megan Danielewicz, Ryan D. Leib, Javier García‐Bermúdez, Desiree Tillo, Andres M. Lebensohn, James A. Olzmann, Rajat Rohatgi, Maia Kinnebrew
This study shows that fatty acid metabolism regulates plasma membrane cholesterol accessibility through ATGL-dependent phospholipid remodeling, affecting membrane fluidity and cholesterol signaling.
bioRxiv · Aug 21, 2025 · PreprintCell Biology