This study examines how bile acid modulation affects colonic epithelial responses in mice and humans, finding altered cell populations and gene expression associated with DCA exposure.

Scientific Reports · Jun 3, 2026Peer-reviewedPhysiology

Blood-borne immune cells carry low biomass DNA remnants of microbes in patients with colorectal cancer or inflammatory bowel disease

Yasser Morsy, Ãsa Walberg, Paulina Wawrzyniak, Barbara Hubeli, Luca Truscello, Céline Mamie, Ania Niechcial, Emilie Gueguen, Roberto Manzini, Claudia Gottier, Silvia Lang, Sylvie Scharl, Sena Blümel, Luc Biedermann, Gerhard Rogler, , Michael M. Scharl

The paper identifies bacterial DNA remnants in blood immune cells of CRC and IBD patients, suggesting microbial translocation via intestinal barrier defects.

Gut Microbes · Jul 20, 2025Peer-reviewedCancer Biology

Genome-wide analysis of 944,133 individuals provides insights into the etiology of hemorrhoidal disease

Tenghao Zheng, David Ellinghaus, Simonas Juzėnas, François Cossais, Greta Burmeister, Gabriele Mayr B, Isabella Friis Jørgensen, Maris Teder‐Laving, Anne Heidi Skogholt, Sisi Chen, Peter R. Strege, Go Ito, Karina Banasik, Thomas Becker, Frank Bokelmann, , André Franke

This study performs a genome-wide association analysis of hemorrhoidal disease in 944,133 individuals, identifying 102 risk loci and linking them to vascular and tissue development pathways.

Gut · Apr 22, 2021Peer-reviewedGenetic & Genomic Medicine