Gerhard Rogler

Resolving inflammatory bowel disease risk variants to genes and cell types

This study identifies 619 IBD risk signals, resolves 81 high-confidence variants, and prioritizes 664 candidate effector genes using GWAS, eQTL, and exome sequencing.

Shifting Perspectives on Biotherapeutic Treatment in Ulcerative Colitis using Lipid Mesophases: Formulation Design and Preclinical Validation

This study develops and validates a localized delivery system for infliximab in ulcerative colitis, showing improved therapeutic efficacy and reduced systemic absorption.

GPR68, a proton-sensing GPCR, mediates acid-induced visceral nociception

This study identifies GPR68 as a mediator of acid-induced colonic nociception through genetic and pharmacological approaches in mice.

Blood-borne immune cells carry low biomass DNA remnants of microbes in patients with colorectal cancer or inflammatory bowel disease

The paper identifies bacterial DNA remnants in blood immune cells of CRC and IBD patients, suggesting microbial translocation via intestinal barrier defects.

Engineering a novel probiotic toolkit in Escherichia coli Nissle1917 for sensing and mitigating gut inflammatory diseases

This paper develops a modular probiotic system in Escherichia coli Nissle1917 that detects nitric oxide and secretes anti-TNF nanobodies to mitigate gut inflammation.

The proton-activated receptor TDAG8 is upregulated in oligodendrocytes during maturation and under acidic conditions.

The paper investigates TDAG8 expression and function in oligodendrocytes under acidic conditions and inflammation, finding upregulation during maturation and in MS lesions.