Robert M. Brownstone

The paper identifies spinal circuits that map trunk regions to control skin twitches in mice, showing somatotopic organization and optogenetic activation of specific motor pathways.

The paper characterizes the cellular and circuit properties of perineal motor control in adult mice, revealing distinct biophysical features and motor unit recruitment patterns during urination.

This study identifies dI3 neurons in the spinal cord that compare efference copies and sensory feedback to enable rapid movement corrections.

This paper introduces a novel behavioural assay to study whole-body motor control during climbing in mice, revealing kinematic features and multi-limb coordination patterns.

This study uses high-density surface EMG and in silico modelling to reveal subject-specific inhibitory spinal microcircuit properties and control strategies.

The paper investigates how spinal microcircuits adapt in a mouse model of motoneuron degeneration, finding specific multiphasic homeostatic compensations that preserve force output.

This study investigates the origin of F-waves in mice, showing they are mediated by spinal microcircuits via glutamatergic synapses from motor axon collaterals.

The paper investigates the spatial organization of spinal premotor interneurons controlling flexor and extensor muscles, finding they are intermingled rather than segregated.

This study shows that KV2.1 channels are not essential for C-bouton mediated enhancement of motoneuron output in mature mice.

This study shows that spinal cord dysfunction contributes to DYT1 dystonia by creating mouse models with dystonia-like symptoms.

The paper investigates spinal neurons that project to multiple motor pools, showing they coordinate activity across joints and mediate co-contraction of antagonist muscles.

This study shows that eliminating glutamatergic transmission from Hb9 interneurons does not impair treadmill locomotion, suggesting these neurons are not essential for locomotor rhythmogenesis.

This study examines adaptations in rat motoneurons and C-boutons under chronic functional overload, finding that motoneuron size decreases while C-boutons remain largely unchanged.

The paper identifies two sub-populations of Chx10-expressing neurons in the mouse medullary reticular formation and shows how local interneurons modulate reticulospinal output.

The paper shows that spinal motoneurons mature electrophysiologically from rostral to caudal during post-natal development in mice, correlating with the arrival of descending systems.

This study identifies opioid-dependent inhibition of neurotransmitter release as the primary mechanism of analgesia in NaV1.7 null mutants in mice and humans.