Hyun O. Lee

Long-read proteogenomic atlas of human neuronal differentiation reveals isoform diversity informing neurodevelopmental risk mechanisms

The paper generates a high-resolution proteogenomic atlas of human neuronal development using long-read RNA sequencing and proteomics, revealing novel isoforms and their role in neurodevelopmental risk mechanisms.

Subnuclear cofactor partitioning underlies auxin-dependent transcriptional regulation

The paper identifies a biochemical mechanism by which the MpARF1 transcription factor activates gene expression through subnuclear clustering and Mediator complex recruitment, revealing an evolutionary innovation in auxin response.

BrainRBPedia: a resource for RNA-binding proteins relevant to neurodevelopmental disorders

BrainRBPedia is a database of 1072 RNA-binding proteins linked to neurodevelopmental disorders, with a machine learning model prioritizing RBPs for autism and intellectual disability.

DNA repair by Rad52 liquid droplets

This study shows that Rad52 proteins in yeast form liquid droplets that facilitate DNA repair by tethering damaged DNA to microtubules.