Nigel Kee

Sox9 and Nfi transcription factors regulate the timing of neurogenesis and ependymal maturation in dopamine progenitors

This study identifies Sox9 and Nfi transcription factors as regulators of G0 entry and ependymal maturation in midbrain dopamine progenitors, with effects dependent on developmental timing.

Posterior specification of multi-lineage axial assembloids from human pluripotent stem cells.

This paper describes a protocol to generate human posterior axial assembloids from pluripotent stem cells, demonstrating multi-lineage differentiation and tissue complexity.

Spatial RNA sequencing identifies robust markers of vulnerable and resistant human midbrain dopamine neurons and their expression in Parkinson's Disease

The paper identifies stable gene markers distinguishing vulnerable SNc and resilient VTA dopamine neurons in humans and shows their expression changes in Parkinson's Disease.

LCM-seq identifies robust markers of vulnerable and resistant human midbrain dopamine neurons

This study identifies robust markers for human midbrain dopamine neurons using LCM-seq, showing they can distinguish SNc and VTA neurons in both human and mouse.

Axon-seq decodes the motor axon transcriptome and its modulation in response to ALS

Axon-seq identifies axon-specific transcripts and ALS-dysregulated genes in motor axons, revealing novel therapeutic targets for motor neuron disease.