Sebastian Wolf

This study shows AML cells use extracellular protein catabolism to supply amino acids and manage nitrogen, with GS/GLUL playing a key role in ammonia buffering and disease progression.

This study identifies CEBPA-N-AML as having enhanced engraftment and defines a novel LSC signature in CEBPA-N-AML.

IntegrateALL is an RNA-seq pipeline that integrates expression-based subtyping, gene fusion detection, and virtual karyotyping to classify B-ALL with high accuracy.

PACMON integrates multi-omics data from perturbation screens to infer pathway-level responses to experimental perturbations, achieving high accuracy and scalability.

GeneCOCOA identifies context-specific functions of individual genes using co-expression data and curated functional gene sets, outperforming existing methods in gene-disease association recall.