Zhitao Hu

Evolutionarily Conserved and Divergent Mechanisms of Dual Ca2+ Sensors in Synaptic Vesicle Exocytosis

This study investigates how SNT-1 and SNT-3 mediate fast and slow neurotransmitter release in C. elegans by analyzing their interactions with SNARE complexes and polybasic motifs.

The claudin-like molecule CLC-3 regulates neuromuscular function in Caenorhabditis elegans by modulating cholinergic signalling

The paper identifies CLC-3 as a claudin-like protein in C. elegans that regulates neuromuscular function by modulating cholinergic signalling through synaptic vesicle organization.

Mechanisms that regulate the C1-C2B mutual inhibition controls functional switch of UNC-13

This study identifies a mechanism by which UNC-13 in C. elegans regulates synaptic vesicle exocytosis through domain interactions and functional switches.

CASK and FARP localize two classes of post-synaptic ACh receptors thereby promoting cholinergic transmission

This study identifies CASK and FARP as scaffolding proteins that localize post-synaptic ACh receptors, enhancing cholinergic transmission in C. elegans.

Male pheromones modulate synaptic transmission at the C. elegans neuromuscular junction in a sexually dimorphic manner

This study shows that male pheromones in C. elegans enhance hermaphrodite cholinergic synaptic transmission at the neuromuscular junction, affecting locomotion and mating efficiency.

Heterodimerization of UNC-13/RIM regulates synaptic vesicle release probability but not priming

The paper shows that UNC-13L's C2A domain forms homodimers or heterodimers with RIM, and that heterodimerization regulates synaptic vesicle release probability but not priming.