Jiayu Chen

The paper investigates CTCF chromatin occupancy during mouse pre-implantation development and identifies ADNP's role in modulating SINE B2-derived CTCF-binding sites.

The paper identifies widespread extrachromosomal circular DNA (eccDNA) formation during spermatogenesis and shows microhomology-mediated end joining is the major biogenesis mechanism.

The paper evaluates eight R-loop mapping technologies, identifies biases and artifacts, and classifies R-loops into two distinct types based on RPA binding patterns.

The paper shows that active retrotransposons produce siRNAs that maintain pericentromeric heterochromatin, ensuring stable genetic inheritance in Drosophila cells.

The paper maps and characterizes RNA elements recognized by human RNA binding proteins in K562 and HepG2 cells, expanding the catalog of functional elements in the human genome.