Author

Collin Gilbreath

Children's Medical CenterORCID 0000-0002-8683-983XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell-cell communication· 2 Assay:ChIP-seq· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Sihan WuiD· 3 shared Jun Yi Stanley LimiD· 2 shared Kailiang QiaoiD· 2 shared Wenyue LiuiD· 2 shared Xiaohui SuniD· 2 shared Yipeng XieiD· 2 shared Yoon Jung KimiD· 2 shared Alice MazzagattiiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCancer Biology

Sihan WuORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Cis and Trans Regulatory Mechanisms of ecDNA Segregation

Yipeng Xie, Jun Yi Stanley Lim, Wenyue Liu, Collin Gilbreath, Xiaohui Sun, Kailiang Qiao, Yoon Jung Kim, Sihan Wu

This study identifies cis and trans regulatory mechanisms governing ecDNA segregation, showing H3K27ac and bromodomain proteins mediate interactions, while inactive Pol II facilitates attachment.

Nature Cell Biology · Jun 24, 2026Peer-reviewedCancer Biology

ecDNA-driven oncogene super-expressors shape immunoevasive tumor microenvironment

Kailiang Qiao, Qing‐Lin Yang, Tuo Li, Xiongfeng Chen, Zeynep Yazgan, Yoon Jung Kim, Collin Gilbreath, Jun Yi Stanley Lim, Yipeng Xie, Xiaohui Sun, Yang Liu, Yiyue Jia, Zhijian J. Chen, Huocong Huang, Sihan Wu

This study shows ecDNA-driven oncogene super-expressors create an immunoevasive tumor microenvironment in PDAC by promoting myCAF expansion and suppressing T cell infiltration.

bioRxiv · Nov 15, 2025 · PreprintCancer Biology

Dual inhibition of ATR and DNA-PKcs radiosensitizes ATM-mutant prostate cancer

Mia E. Hofstad, Andrea Woods, Karla Parra, Zoi E. Sychev, Alice Mazzagatti, Xiaofang Huo, Lan Yu, Collin Gilbreath, Wei‐Min Chen, Anthony J. Davis, Peter Ly, Justin M. Drake, Ralf Kittler

This study shows that dual inhibition of ATR and DNA-PKcs radiosensitizes ATM-deficient prostate cancer cells, with Compound B effectively achieving this in vitro and in vivo.

Oncogene · Mar 21, 2025Peer-reviewedCancer Biology

Chromatin-associated RNA Dictates the ecDNA Interactome in the Nucleus

Zhengyu Liang, Collin Gilbreath, Wenyue Liu, Yan Wang, Michael Q. Zhang, Dong‐Er Zhang, Sihan Wu, Xiang‐Dong Fu

The paper shows that ecDNA interactomes are shaped by nascent RNA, with PVT1 and MYC ecDNA using noncoding RNA for trans-activation, while EGFR ecDNA is less effective due to efficient splicing.

bioRxiv · Jul 27, 2023 · PreprintGenomics