Jean‐Pierre Quivy

Nuclear activities and interactome of the NS5 protein of Tick-Borne Encephalitis Virus

This study identifies the nuclear localization and interactome of TBEV NS5 protein, revealing its role in modulating viral replication through interactions with nuclear factors.

HIRA defines early replication initiation zones independently of their genome compartment

The paper shows HIRA regulates early replication initiation zones independently of chromatin accessibility, histone marks, and 3D compartment organisation.

H3.3 deposition counteracts the replication-dependent enrichment of H3.1 at chromocenters in embryonic stem cells

The paper shows H3.3 deposition counteracts H3.1 enrichment at chromocenters in ESCs, affecting heterochromatin stability and cell survival.

HIRA-dependent provision of histone H3.3 in active chromatin ensures genome compartmentalisation

This study shows that HIRA-dependent histone H3.3 deposition maintains 3D genome compartmentalisation in active chromatin, independent of histone PTMs.