Ellie I. James

This study uses pulsed HDX-MS to investigate whether tau4RD fibril polymorphism is imprinted during early aggregation or arises from structural rearrangements later in the process.

This study reveals how two F-box proteins, FBXO22 and FBXL17, recognize distinct structural features of the BACH1 BTB dimer under oxidative stress, leading to its ubiquitination and degradation.

The paper identifies tryptanthrin analogs as potent substoichiometric inhibitors of tau4RD aggregation, showing low nanomolar potency and demonstrating structure-activity relationship principles for tau targeting.