Stéphane Haı̈k

This paper introduces PrP E219K as a new substrate for RT-QuIC that amplifies multiple human prion strains and enables discrimination between sporadic and variant CJD strains.

This study identifies genetic variants associated with clinical duration in sporadic CJD but finds no significant SNPs for age at onset.

The paper establishes the 3D anatomy of meningeal lymphatic vasculature and CSF drainage in mice and humans using imaging techniques, showing conserved lymphatic structures.

This study shows that injecting human Alzheimer's brain extracts into mice with amyloid-beta plaques induces tau pathology, memory deficits, and synaptic loss, with neuritic plaques linked to synaptic impairment.

This study shows doxycycline reduces α-synuclein aggregation and oxidative stress in vitro and in vivo, suggesting it could treat synucleinopathies like Parkinson's disease.

This paper quantifies the challenges of designing preventive clinical trials for genetic prion disease due to high variability in age of onset, suggesting the need for biomarker-based trials.