Author

Janet N.Y. Chan

University of TorontoORCID 0000-0001-5644-985XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Karim MekhailiD· 3 shared Razqallah HakemiD· 2 shared Anisha K. HundaliD· 1 shared Anne HakemiD· 1 shared Brandon J. PaylissiD· 1 shared Brendan Craig DicksoniD· 1 shared Chris A. JordaniD· 1 shared Chris A. JordaniD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMolecular Biology

Karim MekhailORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Dna2-intrinsic condensation regulates DNA end resection and reveals evolutionary redistribution of condensate grammar

Chris A. Jordan, Jonas Lehar, Brandon J. Payliss, Guillaume Laflamme, Zhongle Liu, Juliana The, Janet N.Y. Chan, Tamari Chkuaseli, Razqallah Hakem, Leah E. Cowen, Haley D.M. Wyatt, Karim Mekhail

This study shows that Dna2 forms condensates that enhance DNA end resection in yeast, with phosphorylation regulating condensate stability and function.

bioRxiv · Sep 18, 2026 · PreprintMolecular Biology

DNA double-strand break-capturing nuclear envelope tubules drive DNA repair

Mitra Shokrollahi, Mia Stanić, Anisha K. Hundal, Janet N.Y. Chan, Defne Urman, Chris A. Jordan, Anne Hakem, Roderic Espín, Jun Hao, Rehna Krishnan, Philipp G. Maass, Brendan Craig Dickson, Manoor Prakash Hande, Miguel Ángel Pujana, Razqallah Hakem, Karim Mekhail

The paper shows that DNA double-strand breaks are repaired by nuclear envelope tubules formed through cytoplasmic microtubule interactions, enhancing repair accuracy and cancer therapy efficacy.

Nature Structural & Molecular Biology · Apr 17, 2024Peer-reviewedMolecular Biology

Locus-associated R-loop repression in cis

Negin Khosraviani, Karan Joshua Abraham, Janet N.Y. Chan, Karim Mekhail

The paper develops a system to modulate R-loops at specific loci using a chimaera protein and applies it to study R-loop functions in cis and trans.

bioRxiv · May 25, 2021 · PreprintMolecular Biology