Leah E. Cowen

This study identifies co-packaging of two antimicrobial compounds in extracellular vesicles, showing enhanced potency against fungal biofilms compared to individual compounds.

This study shows that Dna2 forms condensates that enhance DNA end resection in yeast, with phosphorylation regulating condensate stability and function.

The paper identifies essential transcriptional regulators in Cryptococcus neoformans, highlighting Ezt1 as a key regulator of growth, drug response, and virulence.

The paper identifies butyrolactol A as a compound that enhances caspofungin efficacy against resistant fungi by inhibiting phospholipid flippase, thereby improving antifungal treatment.

The paper identifies structure-activity relationships for diarylpyrazole inhibitors of the fungal kinase Yck2, showing improved selectivity and antifungal activity.

This study adapts the tetracycline-repressible system to regulate essential gene expression in Cryptococcus neoformans, demonstrating its effectiveness in depleting HSP90 and inhibiting fungal growth.

The paper uses chemoproteomic profiling to identify selective anti-fungal kinase inhibitors targeting C. albicans CK1 homologs.

This paper investigates the role of the STRIPAK complex in Cryptococcus neoformans, showing it regulates genome stability, sexual development, and virulence through functional characterization of its subunits.

The paper discovers a pro-nematicide scaffold, Cyprocide, that selectively kills diverse plant-parasitic nematodes through P450 enzyme activation, offering a potential solution for sustainable nematode management.

The paper identifies genetic determinants of chemical resistance in yeast using in vitro evolution and whole genome sequencing, revealing key transcription factors involved in drug resistance.