Author

Guillaume Laflamme

Ottawa Institute of Systems BiologyORCID 0000-0002-9083-4572Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Organism:yeast· 2 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Ànnia Carré SimoniD· 1 shared Brandon J. PaylissiD· 1 shared Cecilia Martuzzi· 1 shared Chris A. JordaniD· 1 shared Damien D’AmoursiD· 1 shared Emmanuelle FabreiD· 1 shared Haley D.M. WyattiD· 1 shared Henrik Dahl PinholtiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCell Biology

Ànnia Carré SimonORCID

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2 papers

Recent·Most cited

Dna2-intrinsic condensation regulates DNA end resection and reveals evolutionary redistribution of condensate grammar

Chris A. Jordan, Jonas Lehar, Brandon J. Payliss, Guillaume Laflamme, Zhongle Liu, Juliana The, Janet N.Y. Chan, Tamari Chkuaseli, Razqallah Hakem, Leah E. Cowen, Haley D.M. Wyatt, Karim Mekhail

This study shows that Dna2 forms condensates that enhance DNA end resection in yeast, with phosphorylation regulating condensate stability and function.

bioRxiv · Sep 18, 2026 · PreprintMolecular Biology

Smc5/6 - microtubules binding shapes pericentromeric chromatin

Ànnia Carré Simon, Cecilia Martuzzi, Sarah Isler, Renaud Batrin, Henrik Dahl Pinholt, Timothy Földes, Guillaume Laflamme, Juan Reguera, Maria Barbi, Leonid A. Mirny, Damien D’Amours, Emmanuelle Fabre

This study shows that Smc5/6 microtubule binding constrains chromatin dynamics and promotes pericentromeric folding in yeast, safeguarding genome stability during mitosis.

iScience · Aug 1, 2026Peer-reviewedCell Biology