Phuong Nguyen

The paper develops a SAMHD1 knockout iPSC model that enhances lentiviral transduction efficiency in myeloid cells, enabling better functional genomics studies in innate immunity and inflammatory diseases.

This paper introduces PerSpecTM, a method to predict antibiotic mechanisms of action by comparing transcriptional responses of new molecules to known perturbations, demonstrating its effectiveness with three new anti-Pseudomonas aeruginosa compounds.

This paper optimizes CRISPR guide RNA library cloning to reduce bias and enables more compact genetic screens with equivalent results using fewer cells.