Author

James S. Ye

The University of Texas Southwestern Medical CenterORCID 0000-0001-5691-6649Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Diana R. TomchickiD· 2 shared Krzysztof PawłowskiiD· 2 shared Vincent S. TagliabracciiD· 2 shared Abir MajumdariD· 1 shared Adam OsinskiiD· 1 shared Brenden C. Park· 1 shared D.N. CooperiD· 1 shared David J. PagliariniiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersMolecular Biology

Diana R. TomchickORCID

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3 papers

Recent·Most cited

Molecular BiologyThe EMBO JournalPeer-reviewedJan 3, 2026

Bacterial ubiquitin ligase engineered for small molecule and protein target identification

James S. Ye, Abir Majumdar, Brenden C. Park…·Vincent S. Tagliabracci

This paper introduces SidBait, a modular proximity ligation approach to identify small molecule and protein targets, validated with known interactions and applied to discover new targets like CaMKII and CapZ.

1 citation

proteomicsexperimental assay

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BiochemistrybioRxivPreprintSep 10, 2025

ACAD10 encodes two orphan enzymes in the ether lipid biosynthetic and salvage pathways

James S. Ye, Elena Purlyte, Víctor A. López…·Vincent S. Tagliabracci

This study identifies ACAD10 as encoding two enzymes involved in ether lipid biosynthesis and salvage, linking them to type 2 diabetes risk.

DOI 10.1101/2025.09.10.675409

mousehuman

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GenomicsNature GeneticsPeer-reviewedFeb 25, 2019

S-CAP extends clinical-grade pathogenicity prediction to genetic variants that affect RNA splicing

Karthik A. Jagadeesh, Joseph M. Paggi, James S. Ye…·Gill Bejerano

S-CAP improves pathogenicity prediction for splicing-relevant variants by reducing uncertain variants by 41% with 95% sensitivity.

62 citationstop 3%

humanwhole-exome sequencing

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