Zhiying Zhang

Brig3, a DNA glycosylase from a soil metagenome, excises 5-hydroxymethylcytosine from T-even phage DNA; the glucose hydrolase BapA extends defense to glucosylated genomes such as wild-type T4.

The paper identifies Pucsar, a bacterial antiphage system that uses 3,5-cGMP generated by a cyclase to activate TIR effectors through a stepwise filament assembly process.

This study investigates how Druantia III and Zorya II antiphage defence systems in bacteria synergize through shared DNA intermediates, showing their coordinated response during phage infection.

This study identifies Tmn as a bacterial membrane protein that blocks phage spread by inducing plasmolysis and activates synergistic defence responses through ATP depletion.

The paper identifies a methylome-derived m6-dAMP trigger that forms an immune filament in E. coli to deplete dNTPs and abort phage infection.

This study reveals the structural basis and evolutionary origin of the Lamassu bacterial immune system, showing its adaptation from DNA repair machinery to detect and respond to viral replication.