Author

Megan E. Meuser

Yale UniversityORCID 0000-0002-1544-606XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:microscopy & imaging analysis· 2 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Organism:virus· 1

Frequent Co-Authors

Christian FreniereiD· 2 shared Christopher AikeniD· 2 shared Chunxiang WuiD· 2 shared Juan R. PerillaiD· 2 shared Rachel YangiD· 2 shared Yong XiongiD· 2 shared Amanda C. MackeiD· 1 shared Hamed MeshkiniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

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10 top collaborators · 42 mutual co-author links

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2 shared papersBiochemistry

Christian FreniereORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJan 11, 2026

A Hybrid Gag Lattice as a Structural Intermediate in HIV-1 Maturation

Megan E. Meuser, Chunxiang Wu, Amanda C. Macke…·Yong Xiong

This study identifies a hybrid Gag lattice as an intermediate in HIV-1 maturation, showing it is stabilized by IP6 and essential for infectivity.

2 citations

𝕏 PostBluesky

BiochemistryJournal of the American Chemical SocietyPeer-reviewedNov 6, 2025

Structural insights into inhibitor mechanisms on immature HIV-1 Gag lattice revealed by high-resolution in situ single-particle cryo-EM

Chunxiang Wu, Megan E. Meuser, Juan S. Rey…·Yong Xiong

This study determines high-resolution structures of immature HIV-1 particles with inhibitors BVM and LEN bound using cryo-EM, revealing their distinct binding mechanisms and effects on Gag lattice architecture.

12 citationstop 3%

𝕏 PostBluesky