Author

Jared Hintzen

Yale University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 3 Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:zebrafish· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 2 Organism:mouse· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Stefania NicoliiD· 5 shared Abhishek KumariD· 2 shared Andrew E. PrendergastiD· 2 shared Anthony J. KoleskeiD· 2 shared Gabriel Baldissera· 2 shared Ivan Fan XiaiD· 2 shared Jason Crawford· 2 shared Joey J. GhersiiD· 2 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersDevelopmental Biology

Stefania NicoliORCID

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Author profile →

5 papers

Recent·Most cited

A mitochondrial program encodes brain vascular reserve

Ivan Fan Xia, Di Zhang, A. Gulhan Ercan‐Sencicek, Tanyeri Barak, Anupama Hemalatha, David G. Gonzalez, Jared Hintzen, Paola Carneiro, Gabriel Baldissera, Marina Carlson, Siyuan Cheng, Fei Han, Xinzhuang Yang, Lu Feng, Nicole J. Lake, , Stefania Nicoli

The paper shows mitochondrial state in zebrafish tip cells encodes brain collateral network topology, with microRNA-125a regulating mitochondrial function to influence vascular resilience.

bioRxiv · Mar 26, 2026 · PreprintDevelopmental Biology

Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions

Keiichiro Tanaka, Minghao Chen, Andrew E. Prendergast, Zhenwu Zhuang, Ali R. Nasiri, Divyesh Joshi, Jared Hintzen, Minhwan Chung, Abhishek Kumar, Arya Mani, Anthony J. Koleske, Jason Crawford, Stefania Nicoli, Martin Alexander Schwartz

This study identifies latrophilin-2 as an upstream mechanosensor for fluid shear stress in endothelial cells, linking it to vascular development and disease.

The EMBO Journal · Jun 17, 2024Peer-reviewedMolecular Biology

Hematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic hemogenic endothelium

Joey J. Ghersi, Gabriel Baldissera, Jared Hintzen, Stephanie A. Luff, Siyuan Cheng, Ivan Fan Xia, Christopher M. Sturgeon, Stefania Nicoli

This study shows that miR-128 regulates HSPC heterogeneity by modulating Wnt and Notch signaling in hemogenic endothelium, leading to lineage-specific biases in zebrafish and human systems.

bioRxiv · Sep 28, 2022 · PreprintDevelopmental Biology

The N-Glycome regulates the endothelial-to-hematopoietic transition

Dionna M. Kasper, Jared Hintzen, Yinyu Wu, Joey J. Ghersi, Hanna K. Mandl, Kevin E. Salinas, William Armero, Zhiheng He, Ying Sheng, Yixuan Xie, Daniel W. Heindel, Eon Joo Park, William C. Sessa, Lara K. Mahal, Carlito B. Lebrilla, , Stefania Nicoli

The paper shows that N-glycan modifications regulate endothelial-to-hematopoietic transition by affecting glycosylation enzymes and HSPC production.

Science · Dec 3, 2020Peer-reviewedDevelopmental Biology

Latrophilins are essential for endothelial junctional fluid shear stress mechanotransduction

Keiichiro Tanaka, Andrew E. Prendergast, Jared Hintzen, Abhishek Kumar, Minhwan Chung, Anthony J. Koleske, Jason Crawford, Stefania Nicoli, Martin Alexander Schwartz

This study identifies latrophilins as essential for endothelial cell mechanotransduction of fluid shear stress through both G protein-dependent and -independent pathways.

bioRxiv · Feb 3, 2020 · PreprintMolecular Biology