Author

Bigitha Bennychen

University of OttawaORCID 0000-0001-5779-2131Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Ahmed Zafer· 1 shared Alex ShepherdiD· 1 shared Andrea Acel· 1 shared Anna N. MoraitisiD· 1 shared Anne MarciliD· 1 shared Annie AdraitiD· 1 shared Annie FortiniD· 1 shared Annie J. Aubry· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

Ahmed Zafer

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Broadly Reactive Anti-VHH Antibodies for Characterizing, Blocking, or Activating Nanobody-Based CAR-T Cells

Scott McComb, Bianca Dupont, Alex Shepherd, Bigitha Bennychen, Anne Marcil, Laura Tamblyn, Shalini Raphael, Joey G. Sheff, Greg Hussack, Anna N. Moraitis, Cunle Wu, Annie J. Aubry, Christine Gadoury, Julie Lippens, Martine Pagé, , Mehdi Arbabi‐Ghahroudi

The paper develops anti-VHH antibodies that target nanobody domains in CAR-T cells, enabling labeling, blocking, and activation of VHH-based CAR-T cells without disrupting antigen binding.

Antibody Therapeutics · Jun 11, 2025Peer-reviewedImmunology

RSL24D1 sustains steady-state ribosome biogenesis and pluripotency translational programs in embryonic stem cells.

Sébastien Durand, Marion Bruelle, Fleur Bourdelais, Bigitha Bennychen, Juliana Blin, Caroline Isaac, Aurélia Huyghe, Sylvie Martel, Antoine Seyve, Christophe Vanbelle, Annie Adrait, Yohann Couté, David Meyronet, Frédéric Catez, Jean‐Jacques Diaz, , Mathieu Gabut

This study identifies RSL24D1 as a key regulator of ribosome biogenesis and pluripotency in mouse embryonic stem cells, showing its role in maintaining self-renewal and suppressing differentiation.

Nature Communications · Jan 23, 2023Peer-reviewedDevelopmental Biology