Maja Gehre

A SUMO-dependent regulatory switch connects the piRNA pathway to the heterochromatin machinery in Drosophila

The paper reveals how the piRNA pathway connects to the heterochromatin machinery in Drosophila through SUMOylation of Panoramix and its interaction with Sov.

The molecular principles of Piwi-mediated co-transcriptional silencing through the dimeric SFiNX complex

This study identifies the role of the SFiNX complex dimerization in enabling co-transcriptional silencing via molecular condensate formation in Drosophila.

The functional landscape of the human phosphoproteome

The paper creates a comprehensive human phosphoproteome by integrating 6,801 phospho-enriched mass spectrometry experiments and prioritizes functional phosphosites using machine learning.

Efficient strategies to detect genome editing and integrity in CRISPR-Cas9 engineered ESCs

The paper describes an experimental strategy for mutating protein residues in mouse ESCs and introduces Mismatch-qPCR for detecting CRISPR editing events, while also showing RNA-Seq and low-coverage sequencing can detect large chromosomal deletions and rearrangements.