Runsheng Chen

This study uses single-cell multi-omics to analyze immune reconstitution failure in HIV patients, identifying genetic and epigenetic factors and developing a predictive model.

The paper introduces CIMA, a multi-omics atlas of human immune cells, identifying regulatory mechanisms and genetic associations across sex, age, and genetic factors.

The paper uses spatial transcriptome analysis in a mouse model of intraventricular haemorrhage to identify 3D gene expression trajectories and neural circuits involved in secondary brain injury.

SmProt provides a comprehensive and reliable repository of small proteins identified from ribosome profiling, including curated data from multiple species and sources.

The paper shows that active retrotransposons produce siRNAs that maintain pericentromeric heterochromatin, ensuring stable genetic inheritance in Drosophila cells.

Ennet identifies cancer-driving networks using somatic enhancer mutations, revealing known and novel networks across multiple cancer types.

This study uses single molecule sequencing of cell-free DNA from maternal plasma to detect trisomy 13, 18, and 21 with improved sensitivity and reduced GC bias compared to NGS.