Ruizhi Peng

CryoSift automates 2D class selection in cryo-EM by using a CNN to assess particle quality, enabling high-throughput processing for high-resolution reconstructions.

This study determines the structure of Drp1 on lipid membranes, revealing a locally ordered lattice and conformational changes that suggest a ratchet mechanism for mitochondrial constriction.

The paper introduces SPOT-RASTR, a cryo-EM technique using lipid nanotubes to overcome air-water interface and preferred orientation issues, enabling automated data collection and near-atomic resolution.