Author

Jason A. Mears

Case Western Reserve UniversityORCID 0000-0002-5199-4872Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Developmental Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1

Frequent Co-Authors

Adina Brett-Morris· 1 shared Ana Katic· 1 shared Anelise N Hutson· 1 shared Anna Leoni SwartiD· 1 shared Carmen BuchrieseriD· 1 shared Donny D. LicatalosiiD· 1 shared Enza VittoriiD· 1 shared Francisco Javier García-RodrígueziD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperDevelopmental Biology

Adina Brett-Morris

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3 papers

Recent·Most cited

The Legionella effector RidL promotes mitochondrial fragmentation through phosphorylation activation of the large GTPase Drp1

Ana Katic, Enza Vittori, Stefanie Halter, Kevin Steiner, Anna Leoni Swart, Milad Radiom, Francisco Javier García-Rodríguez, Tobias Jaggi, Xiaodan Li, Jason A. Mears, Carmen Buchrieser, Pedro Escoll, Vikram Govind Panse, Hubert Hilbi

This study identifies RidL as a bifunctional effector that inhibits retrograde trafficking and promotes mitochondrial fragmentation by phosphorylating Drp1, aiding Legionella pneumophila's intracellular survival.

EMBO Reports · Jun 6, 2026Peer-reviewedMicrobiology

The Structure of the Drp1 Lattice on Membrane

Ruizhi Peng, Kristy Rochon, Anelise N Hutson, Scott M. Stagg, Jason A. Mears

This study determines the structure of Drp1 on lipid membranes, revealing a locally ordered lattice and conformational changes that suggest a ratchet mechanism for mitochondrial constriction.

Journal of Molecular Biology · Apr 3, 2025Peer-reviewedBiochemistry

PTBP2-dependent alternative splicing regulates protein transport and mitochondria morphology in post-meiotic germ cells.

Molly M. Hannigan, Hisashi Fujioka, Adina Brett-Morris, Jason A. Mears, Donny D. Licatalosi

This study shows that PTBP2 regulates alternative splicing in post-meiotic germ cells, affecting protein trafficking and mitochondria morphology through splicing-dependent gene regulation.

bioRxiv · Dec 15, 2018 · PreprintDevelopmental Biology