Lina Zheng

Long-term maintenance of patient-specific characteristics in tumoroids from six cancer indications in a common base culture media system

This study shows that tumoroids from six cancer types can be maintained long-term in a standardized serum-free medium, preserving their genetic and phenotypic features.

CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription

Functional characterization of gene regulatory elements and neuropsychiatric disease-associated risk loci in iPSCs and iPSC-derived neurons

The paper identifies functional CREs in iPSCs and neurons and links them to neuropsychiatric disease risk variants.

Parallel Characterization of cis-Regulatory Elements for Multiple Genes Using CRISPRpath

CRISPRpath enables parallel characterization of cis-regulatory elements for multiple genes in a pathway, identifying functional enhancers and distinguishing their impact on gene expression.

Identification of DNA motifs that regulate DNA methylation

The paper identifies DNA motifs associated with methylation and unmethylation and shows their functional relevance in DNA methylation regulation and cancer.