Pierre‐Henri Commère

Biogenesis of DNA-carrying extracellular vesicles by the dominant human gut methanogenic archaeon

This study characterizes DNA-carrying extracellular vesicles (EVs) from Methanobrevibacter smithii, revealing their role in DNA and protein export in the gut.

Purification protocol of hypertrophied hepatic stellate cells for their transcriptomic characterization from CDAHFD mice liver

The paper describes a protocol to purify hypertrophied hepatic stellate cells (hypHSCs) from CDAHFD mice and performs bulk RNA-seq to show their distinct molecular signature compared to quiescent HSCs.

Extracellular vesicle production and membrane uptake promote repair and antibiotic tolerance in E. coli

This study shows that extracellular vesicles in E. coli sequester and remove antibiotics, repair membranes, and enhance survival without conferring resistance.

Altered RNA-processing provides a mechanistic framework delineating human sex reversal associated with pathogenic variants in the RNA-helicase DHX37

This study identifies how DHX37 variants disrupt RNA processing and gene expression in Sertoli-like cells, leading to 46,XY sex reversal.

In-vitro cellular reprogramming to model gonad development and its disorders

This paper describes in-vitro protocols to differentiate mouse and human pluripotent cells into gonadal progenitors, revealing their functional equivalence to in-vivo cells and modeling DSDs.

Transcriptome and epigenome diversity and plasticity of muscle stem cells following transplantation

This study identifies molecular differences between extraocular and limb muscle stem cells, showing that EOM MuSCs reprogram their transcriptome and epigenome after transplantation, with some genes resisting engraftment.

Ageing affects DNA methylation drift and transcriptional cell-to-cell variability in muscle stem cells

This study shows that ageing increases transcriptional heterogeneity and DNA methylation drift in muscle stem cells, disrupting transcriptional networks and stem cell function.