Danielle J. Smyth

This study investigates the evolutionary adaptation of helminth immunomodulators by analyzing the ARI family in different nematode species and their interactions with host IL-33 and heparan sulphate.

This paper investigates the role of mast cell ST2 in Heligmosomoides polygyrus bakeri infection using transcriptomic and proteomic analysis, finding minimal impact on infection outcomes.

The paper identifies a helminth-derived CCP domain protein, HpBoRB, that binds RELMβ, a host protein with anti-helminth properties, suggesting a mechanism of immune evasion.

This paper shows that vaccinating against helminth IL-33-modulators can protect against infection by reversing immunosuppression and enhancing Th2 immunity.