Abhishek Jamwal

This paper describes the structure of HpBARI2, a helminth-derived protein that trimerises to selectively inhibit membrane-bound ST2 receptor signaling by blocking IL-33 binding and preventing co-receptor recruitment.

This study investigates the evolutionary adaptation of helminth immunomodulators by analyzing the ARI family in different nematode species and their interactions with host IL-33 and heparan sulphate.

The paper identifies a helminth-derived CCP domain protein, HpBoRB, that binds RELMβ, a host protein with anti-helminth properties, suggesting a mechanism of immune evasion.

The paper shows that DNA and heparan sulphate binding prolongs the in vivo half-life of HpARI1 and HpARI2 proteins compared to HpARI3.