Author

Florent Colomb

University of Dundee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:comparative / phylogenetic analysis· 1 Research Focus:drug response / drug discovery· 1 Organism:non-human primate· 1 Organism:rat· 1

Frequent Co-Authors

Henry J. McSorleyiD· 3 shared Abhishek JamwaliD· 2 shared Adefunke OgunkanbiiD· 2 shared Danielle J. SmythiD· 2 shared Matthew K. HigginsiD· 2 shared Tania G. Frangova· 2 shared Alice R SavageiD· 1 shared Amy B. PederseniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersImmunology

Henry J. McSorleyORCID

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3 papers

Recent·Most cited

Evolutionary adaptation of helminth immunomodulators to their hosts

Beatrice Ward, Abhishek Jamwal, Florent Colomb, Adefunke Ogunkanbi, Olivia Fleming, Sophie Darroch, Findlay A J Donnelly, Lucy Gregory, Danielle J. Smyth, Amy B. Pedersen, Lewis Stevens, E. Suzanne Cohen, Matthew K. Higgins, Henry J. McSorley

This study investigates the evolutionary adaptation of helminth immunomodulators by analyzing the ARI family in different nematode species and their interactions with host IL-33 and heparan sulphate.

bioRxiv · Sep 4, 2026 · PreprintImmunology

Vaccination against helminth IL-33-modulators permits immune-mediated parasite ejection

Danielle J. Smyth, Suzanne H. Hodge, Nicole W. P. Ong, Josh Richards, Florent Colomb, Samuele Di Carmine, Vivien Shek, Tania G. Frangova, Marta Campillo Poveda, Rick M. Maizels, Henry J. McSorley

This paper shows that vaccinating against helminth IL-33-modulators can protect against infection by reversing immunosuppression and enhancing Th2 immunity.

Cell Reports · May 1, 2025Peer-reviewedImmunology

Heparan sulphate binding controls in vivo half-life of the HpARI protein family

Florent Colomb, Abhishek Jamwal, Adefunke Ogunkanbi, Tania G. Frangova, Alice R Savage, Sarah A. Kelly, Gavin James Wright, Matthew K. Higgins, Henry J. McSorley

The paper shows that DNA and heparan sulphate binding prolongs the in vivo half-life of HpARI1 and HpARI2 proteins compared to HpARI3.

eLife · Aug 27, 2024Peer-reviewedImmunology