Wesley A. Wierson

This paper describes a persistent AI scientist system that operates continuously, improves through memory and feedback, and generates hypotheses and scientific outputs over time.

The paper develops a CRISPR/Cas9-based method to generate Cre/lox regulated conditional gene alleles in zebrafish, enabling cell-type specific gene inactivation.

This paper characterizes ErCas12a, a new CRISPR/Cas system, showing it enables efficient DNA repair and gene integration in zebrafish and human cells.

GeneWeld enables efficient and precise targeted integration in multiple species using CRISPR/Cas9 with minimal homology arms.

This paper shows Rbbp4 is essential for zebrafish neurogenesis and prevents DNA damage and Tp53-dependent apoptosis in rb1 mutant neural progenitors.