Andrew R. Ouellette

This study evaluates the effects of hippocampal DLGAP2 overexpression on cognition, synaptic function, and dendritic spines in an AD mouse model, finding impaired synaptic plasticity and worsened memory deficits.

This study identifies gene-diet interactions that influence cognitive resilience to Alzheimer's disease in mice, finding a diet-dependent genetic locus associated with resilience.

The paper analyzes genetic diversity's effect on brain composition in an Alzheimer's disease mouse model using an enhanced QUINT workflow.

The paper identifies a cell-type specific signature of cognitive resilience to Alzheimer's disease in human and mouse models, highlighting excitatory intratelencephalic cortical neurons and several resilience genes.

This study shows that genetic background strongly influences sensorimotor decline in AD-BXD mice, which is independent of cognitive decline and dementia.