Catherine Cook Kaczorowski

This paper describes a protocol that combines electrophysiological and proteomic analysis to link protein abundance with neuronal excitability in individual neurons.

This paper examines how beta-amyloid affects static and dynamic functional connectomes in mice and humans, finding species-specific differences in network stability and dynamics.

The paper identifies the Pgb1 locus as controlling glycogen aggregation in aged hippocampal astrocytes without affecting cognitive function.

This study identifies sex-specific gene expression associations with Alzheimer's disease neuropathology and cognitive decline using single-nucleus RNA sequencing from human brain tissue.

This study evaluates the effects of hippocampal DLGAP2 overexpression on cognition, synaptic function, and dendritic spines in an AD mouse model, finding impaired synaptic plasticity and worsened memory deficits.

This study identifies gene-diet interactions that influence cognitive resilience to Alzheimer's disease in mice, finding a diet-dependent genetic locus associated with resilience.

This study quantifies the impact of Alzheimer's disease mutations on brain regions in mice, revealing bidirectional volume changes and sex-specific effects.

The paper analyzes genetic diversity's effect on brain composition in an Alzheimer's disease mouse model using an enhanced QUINT workflow.

This study examines the effects of 2-deoxyglucose on gene expression across nine tissues in mice, identifying tissue-specific changes in metabolic and immunological pathways.

The paper identifies a genetic locus and protein associated with resilience to cognitive decline in AD-BXD mice and links it to human AD traits.

This study shows genetic background affects the proteome in 5XFAD AD mouse models, with some disease-related modules influenced by genetic background while others are not.

RNA Strain-Match matches RNA sequencing alignment data to genotype without variant call files, correcting 13% of sample mismatches in mouse models.

The paper identifies a cell-type specific signature of cognitive resilience to Alzheimer's disease in human and mouse models, highlighting excitatory intratelencephalic cortical neurons and several resilience genes.

The paper identifies hypothalamic gene network dysfunction in AD mice, linking it to cognitive decline and body weight loss through RNA sequencing and network analysis.

The paper examines how diet and genetics interact to affect longevity and weight gain in mice, finding that genetic differences significantly influence the impact of high-fat diets on lifespan.

This study shows that high-fat diet causes AgRP neurons to lose GABAergic inhibition, leading to persistent hyperexcitability despite increased inhibitory input.

This study identifies genetic variants and pathways associated with cognitive resilience to Alzheimer's disease, finding a novel locus linked to bile acid metabolism and methylation changes.

This study shows that genetic background strongly influences sensorimotor decline in AD-BXD mice, which is independent of cognitive decline and dementia.

The paper identifies a functional non-coding variant in the GABRA2 gene of the C57BL/6J mouse strain, showing its impact on Gabra2 expression and implications for neuroscience research.

This study identifies genetic modifiers of Alzheimer’s disease using a humanized mouse model and finds Trpc3 as a novel therapeutic target.