Kristen M. S. O’Connell

This study investigates how diet and age affect AgRP/NPY neuronal activity in female mice, finding sex and age-dependent responses to high-fat diets.

This study evaluates the effects of hippocampal DLGAP2 overexpression on cognition, synaptic function, and dendritic spines in an AD mouse model, finding impaired synaptic plasticity and worsened memory deficits.

This study identifies gene-diet interactions that influence cognitive resilience to Alzheimer's disease in mice, finding a diet-dependent genetic locus associated with resilience.

The paper analyzes genetic diversity's effect on brain composition in an Alzheimer's disease mouse model using an enhanced QUINT workflow.

RNA Strain-Match matches RNA sequencing alignment data to genotype without variant call files, correcting 13% of sample mismatches in mouse models.

The paper identifies a cell-type specific signature of cognitive resilience to Alzheimer's disease in human and mouse models, highlighting excitatory intratelencephalic cortical neurons and several resilience genes.

The paper identifies hypothalamic gene network dysfunction in AD mice, linking it to cognitive decline and body weight loss through RNA sequencing and network analysis.

This paper develops a cross-species platform to model human disease using genetically diverse mouse and human stem cells, showing that DYRK1A loss of function effects vary with genetic background.

This study shows that high-fat diet causes AgRP neurons to lose GABAergic inhibition, leading to persistent hyperexcitability despite increased inhibitory input.

This study shows that genetic background strongly influences sensorimotor decline in AD-BXD mice, which is independent of cognitive decline and dementia.

This study identifies genetic modifiers of Alzheimer’s disease using a humanized mouse model and finds Trpc3 as a novel therapeutic target.