Author

Maria A. Telpoukhovskaia

Gladstone InstitutesORCID 0000-0002-5237-4042Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 7 Approach:experimental assay· 5 Organism:human· 5 Approach:statistical model· 5 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Assay:scRNA-seq· 4

Frequent Co-Authors

Li GaniD· 4 shared Catherine Cook KaczorowskiiD· 3 shared Kristen M. S. O’ConnelliD· 3 shared Niran HadadiD· 3 shared Shiaoching GongiD· 3 shared Yungui Zhou· 3 shared Amy R. DunniD· 2 shared Andrew R. OuelletteiD· 2 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersNeuroscience

Li GanORCID

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Author profile →

8 papers

Recent·Most cited

SupeRJump: Determining normal and leukemic differentiation fate through semi-supervised jump diffusion modeling

Michael Bowman, Roopsha Bandopadhyay, Varsha Singh, Maria A. Telpoukhovskaia, Robert Vander Velde, Sydney M. Shaffer, Jennifer J. Trowbridge, Robert L. Bowman

SupeRJump identifies differentiation fate and discontinuous transitions in leukemia using a semi-supervised jump diffusion model applied to scRNA-seq data.

bioRxiv · Jul 7, 2026 · PreprintBioinformatics

Soluble DLK1 secreted by telomere-shortening-induced senescent microglia impairs oligodendrocyte functions and alters neuronal activity

Bangyan Liu, Matthew Mahoney, Yilin Feng, Maria A. Telpoukhovskaia, Alice Maria Giani, Eileen Ruth Torres, Lihong Zhan, Pearly Ye, Jingjie Zhu, Nessa R. Foxe, Daphne Zhu, Xinran Tong, Deepak Srivastava, Christina V. Theodoris, Shiaoching Gong, , Li Gan

This study identifies soluble DLK1 from senescent microglia as a factor impairing oligodendrocyte function and altering neuronal activity in aging.

bioRxiv · Jan 15, 2026 · PreprintNeuroscience

Detecting the effect of genetic diversity on brain composition in an Alzheimer's disease mouse model

Brianna Gurdon, Sharon C. Yates, Gergely Csucs, N. E. Groeneboom, Niran Hadad, Maria A. Telpoukhovskaia, Andrew R. Ouellette, Tionna B. Ouellette, Kristen M. S. O’Connell, Surjeet Singh, Thomas J. Murdy, Erin Merchant, Ingvild Elise Bjerke, Heidi Kleven, Ulrike Schlegel, , Catherine Cook Kaczorowski

The paper analyzes genetic diversity's effect on brain composition in an Alzheimer's disease mouse model using an enhanced QUINT workflow.

Communications Biology · May 20, 2024Peer-reviewedNeuroscience

RNA Strain-Match: A tool for matching single-nucleus, single-cell, or bulk RNA-sequencing alignment data to its corresponding genotype

Jon A. L. Willcox, Maria A. Telpoukhovskaia, Niran Hadad, Stephanie M. Boas, Amy R. Dunn, Michael C. Saul, David George Ashbrook, Robert W. Williams, Kristen M. S. O’Connell, Catherine Cook Kaczorowski

RNA Strain-Match matches RNA sequencing alignment data to genotype without variant call files, correcting 13% of sample mismatches in mouse models.

bioRxiv · Jul 14, 2023 · PreprintBioinformatics

Conserved cell-type specific signature of resilience to Alzheimer's disease nominates role for excitatory intratelencephalic cortical neurons

Maria A. Telpoukhovskaia, Niran Hadad, Brianna Gurdon, Yanchao Dai, Andrew R. Ouellette, Sarah M. Neuner, Amy R. Dunn, Jon A. L. Willcox, Yiyang Wu, Logan C. Dumitrescu, Orhan Bellur, Jigang Zhang, Kristen M. S. O’Connell, Eric B. Dammer, Nicholas T. Seyfried, , Catherine Cook Kaczorowski

The paper identifies a cell-type specific signature of cognitive resilience to Alzheimer's disease in human and mouse models, highlighting excitatory intratelencephalic cortical neurons and several resilience genes.

bioRxiv · Apr 12, 2022 · PreprintNeuroscience

Tau interactome mapping reveals dynamic processes in synapses and mitochondria associated with neurodegenerative disease

Tara E. Tracy, Jesús Madero‐Pérez, Danielle L. Swaney, Timothy S. Chang, Michelle Moritz, Csaba Konràd, Michael Emmerson Ward, Erica J. Stevenson, Ruth Hüttenhain, Grant Kauwe, María del Pilar Hernández Mercedes, Lauren Sweetland-Martin, Xu Chen, Sue‐Ann Mok, Man Ying Wong, , Li Gan

The paper maps Tau interactomes in neurons using APEX and AP-MS to reveal activity-dependent interactions and FTD mutation effects on mitochondrial associations in neurodegenerative diseases.

Cell · Jan 20, 2022Peer-reviewedNeuroscience

AD-linked R47H-TREM2 mutation induces disease-enhancing proinflammatory microglial states in mice and humans

Faten A. Sayed, Lay Kodama, Joe C. Udeochu, Li Fan, Gillian Carling, David Le, Qingyun Li, Lu Zhou, Hansruedi Mathys, Minghui Wang, Xiang Niu, Linas Mažutis, Xueqiao Jiang, Xueting Wang, Man Ying Wong, , Li Gan

This study identifies R47H-TREM2 mutation-induced proinflammatory microglial states in human AD and tauopathy mice, showing Akt pathway involvement and potential therapeutic targets.

bioRxiv · Jul 24, 2020 · PreprintNeuroscience

Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain

Lihong Zhan, Grietje Krabbe, Fei Du, Ian Richard Jones, Meredith C. Reichert, Maria A. Telpoukhovskaia, Lay Kodama, Chao Wang, Seo-Hyun Cho, Faten A. Sayed, Yaqiao Li, David Le, Yungui Zhou, Yin Shen, Brian L. West, Li Gan

This study shows that adult microglia self-renew to restore homeostasis after ablation, with specific maturation programs and spatial organization.

PLoS Biology · Feb 8, 2019Peer-reviewedNeuroscience