Amy R. Dunn

This study identifies sex-specific gene expression associations with Alzheimer's disease neuropathology and cognitive decline using single-nucleus RNA sequencing from human brain tissue.

This study identifies gene-diet interactions that influence cognitive resilience to Alzheimer's disease in mice, finding a diet-dependent genetic locus associated with resilience.

This study shows that SV2C enhances dopamine and neurotoxicant storage in vesicles, reducing dopaminergic neuron vulnerability.

The paper identifies a genetic locus and protein associated with resilience to cognitive decline in AD-BXD mice and links it to human AD traits.

This study shows genetic background affects the proteome in 5XFAD AD mouse models, with some disease-related modules influenced by genetic background while others are not.

RNA Strain-Match matches RNA sequencing alignment data to genotype without variant call files, correcting 13% of sample mismatches in mouse models.

The paper identifies a cell-type specific signature of cognitive resilience to Alzheimer's disease in human and mouse models, highlighting excitatory intratelencephalic cortical neurons and several resilience genes.

The paper identifies hypothalamic gene network dysfunction in AD mice, linking it to cognitive decline and body weight loss through RNA sequencing and network analysis.

This study shows that genetic background strongly influences sensorimotor decline in AD-BXD mice, which is independent of cognitive decline and dementia.

This study shows that increased tyrosine hydroxylase activity in mice leads to higher dopamine levels, amphetamine response, and oxidative stress markers, suggesting a potential mechanism for neurodegeneration in Parkinson's disease.