Author

Hengyi Xu

The University of Texas at AustinORCID 0000-0001-9809-4882Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Biochemistry· 1 Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:database / resource· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Alan M. LambowitziD· 4 shared Jun YaoiD· 4 shared Douglas C. WuiD· 2 shared Elizabeth A. Ferrick-KiddieiD· 2 shared Alan M Lambowitz· 1 shared Benjamin T Jones· 1 shared Bing Song· 1 shared Dennis WylieiD· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersMolecular Biology

Alan M. LambowitzORCID

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5 papers

Recent·Most cited

A bacterial PrimPol-reverse transcriptase hybrid protein has a proofreading exonuclease activity that can be transferred to other reverse transcriptases

Seungjin Kim, Hengyi Xu, Georg Mohr, Jun Yao, Yan Zhang, Guzhen Cui, Alan M. Lambowitz

bioRxiv · Sep 7, 2025 · PreprintMolecular Biology

Biochemical and structural insights into a 5' to 3' RNA ligase reveal a potential role in tRNA ligation

Yingjie Hu, Victor A Lopez, Hengyi Xu, James P Pfister, Bing Song, Kelly A. Servage, Masahiro Sakurai, Benjamin T Jones, Joshua T. Mendell, Tao Wang, Jun Wu, Alan M Lambowitz, Diana R. Tomchick, Krzysztof Pawłowski, Vincent S. Tagliabracci

This study identifies C12orf29 as an RNA ligase that ligates tRNA and alters tRNA levels in mice, with structural insights into its catalytic mechanism.

Institutional Repositories DataBase (IRDB) · Oct 15, 2024Peer-reviewedBiochemistry

Human cells contain myriad excised linear intron RNAs with links to gene regulation and potential utility as biomarkers

Jun Yao, Hengyi Xu, Elizabeth A. Ferrick-Kiddie, Ryan M. Nottingham, Douglas C. Wu, Manuel Ares, Alan M. Lambowitz

The paper identifies thousands of FLEXIs in human cells, links them to RNA-binding proteins, and suggests their potential as biomarkers.

PLoS Genetics · Sep 26, 2024Peer-reviewedMolecular Biology

TGIRT-seq of Inflammatory Breast Cancer Tumor and Blood Samples Reveals Widespread Enhanced Transcription Impacting RNA splicing and Intronic RNAs in Plasma

Dennis Wylie, Xiaoping Wang, Jun Yao, Hengyi Xu, Elizabeth A. Ferrick-Kiddie, Toshiaki Iwase, Savitri Krishnamurthy, Naoto Tada Ueno, Alan M. Lambowitz

This study uses TGIRT-seq to analyze IBC tumor and blood samples, revealing widespread transcriptional changes and RNA splicing impacts in plasma.

medRxiv · May 26, 2023 · PreprintGenetic & Genomic Medicine

Improved TGIRT-seq methods for comprehensive transcriptome profiling with decreased adapter dimer formation and bias correction

Hengyi Xu, Jun Yao, Douglas C. Wu, Alan M. Lambowitz

The paper improves TGIRT-seq methods by reducing adapter dimer formation and correcting 5- and 3-end biases, enhancing transcriptome coverage and library construction efficiency.

Scientific Reports · May 28, 2019Peer-reviewedGenomics