Shinichi Morishita

This study identifies dysregulation of the p16-CDK6 axis in HPV-unrelated p16-positive oropharyngeal carcinomas, revealing a distinct molecular mechanism and clinical implications.

The paper presents a new gap-free, telomere-to-telomere reference genome for C. elegans, CGC1, improving upon previous assemblies and providing a more complete genome.

This study shows that early-life high-fat diet in medaka fish causes both reversible and persistent epigenetic changes in the liver, affecting metabolic genes and disease-related pathways.

This study identifies a new susceptibility locus, PLA2G4C, for Multiple System Atrophy through a genome-wide association study and functional analysis of a risk variant.

The paper examines genome architecture changes during medaka gastrulation, finding that CTCF loops form while CTCF binding sites remain fixed, and transcription precedes mature domain formation.

This study investigates piRNA size variations and PIWI protein dynamics during hamster oocyte maturation, revealing stage-specific piRNA binding and transcriptional regulation in ovarian piRNA clusters.

The paper uses long-read sequencing to analyze human centromere sequences, revealing substantial structural diversity and novel higher-order repeats across individuals.

The paper develops an algorithm to measure CpG methylation in repetitive elements using SMRT sequencing, achieving high sensitivity and precision in medaka and human genomes.