Marc Hammarlund

The paper identifies oscillatory gene expression in specific cell types using single-cell RNA sequencing and computational methods, finding that cuticle-producing cells exhibit oscillatory patterns while neurons and muscle do not.

CellSpliceNet predicts alternative splicing outcomes in C. elegans neurons by integrating multiple data modalities and achieving high predictive accuracy.

This study shows that neuronal β-spectrin/UNC-70 is essential for axon integrity in C. elegans motor neurons throughout their lifespan.

The paper integrates bulk and single-cell RNA-seq data from C. elegans neurons to improve transcript detection and differential gene analysis.

The paper identifies mitochondria as the transport vehicle for ribosomes to dendrites in C. elegans sensory neurons, showing that MIRO-1 is required for this process.

The paper presents an atlas of alternative splicing in C. elegans neurons, identifies novel splicing events, and describes regulatory patterns and networks.

The paper uses a biosensor to image glycolysis in individual neurons of C. elegans, revealing diverse and adaptable glycolytic states across cell types and conditions.

The paper shows that blocking programmed cell death in C. elegans leads to extra neurons that alter specific behaviors like reversal frequency and duration.

This study identifies OGT-mediated O-GlcNAcylation of HK1 as a mechanism regulating glycolytic metabolon assembly on mitochondria, enhancing ATP production and synaptic function.

The paper identifies VAB-8/KIF26 as a key molecule mediating synaptic cargo delivery at microtubule minus-ends, linking Neurexin and Frizzled signaling to synapse formation in C. elegans.

The paper integrates bulk and single-cell RNA-seq data from C. elegans neurons to improve transcript detection and differential gene analysis.

The paper identifies the CaMKII-Sarm1-ASK1 pathway as a neuroprotective mechanism against axon degeneration caused by mitochondrial loss in C. elegans.

The paper provides a comprehensive gene expression profile of all 302 neurons in the C. elegans nervous system and identifies cis-regulatory elements and adhesion proteins involved in synaptic specificity.

The paper compares two RNA-seq library preparation methods for C. elegans, finding that SoLo Ovation with a custom rRNA depletion kit improves detection of noncoding RNAs and reduces noise in lowly expressed genes.

This study identifies rab-27 in C. elegans intestines as a regulator that inhibits axon regeneration through a neuropeptide secretion pathway.

The paper identifies a functional non-coding RNA derived from xbp-1 mRNA cleavage in C. elegans neurons, showing it is essential for axon regeneration independent of the protein-coding function of xbp-1.

Transcriptomes of 52,412 neurons resolve 109 of the 118 canonical hermaphrodite neuron classes, and neuropeptide genes separate subtypes inside individual classes.

This study shows that axon regeneration alone is insufficient for functional recovery; synapse reformation and function are also critical, and correcting information transfer improves behavioral recovery.

This study identifies APL-1 as an inhibitor of axon regeneration in C. elegans motor neurons, showing it acts through the E2 domain and interacts with Rab6/RAB-6.2.