The paper compares genome-wide data from opioid use and dependence cases to identify genetic associations and differences between exposure and dependence.

Molecular Psychiatry · Feb 25, 2020Peer-reviewedGenetics

Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism

Manav Kapoor, Jen‐Chyong Wang, Sean P. Farris, Yunlong Liu, Jeanette N. McClintick, Ishaan Gupta, Jacquelyn Leigh Meyers, Sarah E. Bertelsen, Michael J. Chao, John I. Nürnberger, Jay A. Tischfield, Oscar Harari, Zeran Li, VICTOR M. HESSELBROCK, Lance O. Bauer, , Alison Goate

The paper identifies 129 differentially expressed genes in the PFC of alcoholics and links them to pathways and modules associated with alcohol dependence and consumption.

Translational Psychiatry · Feb 14, 2019Peer-reviewedNeuroscience

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Raymond Kenney Walters, Renato A Polimanti, Emma C. Johnson, Jeanette N. McClintick, Mark J. Adams, Amy E. Adkins, Fazil Alıev, Silviu‐Alin Bacanu, Anthony J. Batzler, Sarah E. Bertelsen, Joanna M. Biernacka, Tim B. Bigdeli, Li‐Shiun Chen, Toni‐Kim Clarke, Yi‐Ling Chou, , Norbert Wodarz

This study conducts a trans-ancestral GWAS of alcohol dependence, identifying genetic variants and correlations with psychiatric disorders.

Nature Neuroscience · Nov 19, 2018Peer-reviewedGenetics