Lynette C. Foo

The paper investigates how ApoE4 affects intracellular trafficking and iron homeostasis in human brain endothelial cells derived from iPSCs, showing altered endosomal organization and iron levels.

The paper uses single nuclei RNAseq to identify distinct glial gene expression patterns in MS patients, revealing subgroup-specific pathological processes and suggesting precision medicine approaches.

This study uses single-nucleus and spatial transcriptomics to identify cell type-specific associations with Alzheimer's disease pathology in human temporal cortex and white matter.